Scholarship @ UWindsor

Scholarship @ UWindsor is the institutional repository of the University of Windsor (UWindsor), showcasing and preserving the UWindsor community’s scholarly outputs, as well as items from the Leddy Library’s Archives & Special Collections. Its mission is to disseminate and preserve knowledge created or housed at the University of Windsor.

Contact scholarship@uwindsor.ca for more information.

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Conferences and Conference Proceedings 3167
Papers, presentations and abstracts of conferences held at the University of Windsor, in person and virtually.
Digitized Local Collections 1552
Digitized local items from the collections of the Leddy Library, University of Windsor, and community partners.
Faculties, Departments and Research Units 3184
Open Access Faculty publications, reports and working papers from academic departments at the University of Windsor.
Theses, Dissertations, and Major Papers 9577
Formal graduate original research from the University of Windsor's Masters and Doctoral programs.

Recent Submissions

Access status: Open Access ,
Behavioral, Endocrine, and Neuronal Responses to Odors in Lampreys
(MDPI, 2025-07-08) Beauséjour, Philippe-Antoine; Zielinski, Barbara S.; Dubuc, Réjean
Lampreys are primitive fish that rely significantly on olfactory cues throughout their complex life cycle. The olfactory system of the sea lamprey (Petromyzon marinus) is among the best characterized in vertebrates. In recent decades, tremendous advances have been made by isolating individual compounds from sea lampreys that can replicate natural behavior when artificially applied in the wild. In no other aquatic vertebrate has the olfactory ecology been described in such extensive detail. In the first section, we provide a comprehensive review of olfactory behaviors induced by specific, individual odorants during every major developmental stage of the sea lamprey in behavioral contexts such as feeding, predator avoidance, and reproduction. Moreover, pheromonal inputs have been shown to induce neuroendocrine responses through the hypothalamic-pituitary-gonadal axis, triggering remarkable developmental and physiological effects, such as gametogenesis and increased pheromone release. In the second section of this review, we describe a hypothetical endocrine signaling pathway through which reproductive fitness is increased following pheromone detection. In the final section of this review, we focus on the neuronal circuits that transform olfactory inputs into motor output. We describe specific brain signaling pathways that underlie odor-evoked locomotion. Furthermore, we consider possible modulatory inputs to these pathways that may induce plasticity in olfactory behavior following changes in the external or internal environment. As a whole, this review synthesizes previous and recent progress in understanding the behavioral, endocrine, and neuronal responses of lampreys to chemosensory signals.
Access status: Open Access ,
Insights into Active Site Cysteine Residues in Mycobacterium tuberculosis Enzymes: Potential Targets for Anti-Tuberculosis Intervention
(MDPI, 2025-04-18) Faponle, Abayomi S.; Gauld, James W.; de Visser, Sam P.
Cysteine, a semi-essential amino acid, is found in the active site of a number of vital enzymes of the bacterium Mycobacterium tuberculosis (Mtb) and in particular those that relate to its survival, adaptability and pathogenicity. Mtb is the causative agent of tuberculosis, an infectious disease that affects millions of people globally. Common anti-tuberculosis targets are focused on immobilizing a vital cysteine amino acid residue in enzymes that plays critical roles in redox and non-redox catalysis, the modulation of the protein, enzyme activity, protein structure and folding, metal coordination, and posttranslational modifications of newly synthesized proteins. This review examines five Mtb enzymes that contain an active site cysteine residue and are considered as key targets for anti-tuberculosis drugs, namely alkyl hydroperoxide reductase (AhpC), dihydrolipoamide dehydrogenase (Lpd), aldehyde dehydrogenase (ALDH), methionine aminopeptidase (MetAP) and cytochromes P450. AhpC and Lpd protect Mtb against oxidative and nitrosative stress, whereas AhpC neutralizes peroxide/peroxynitrite substrates with two active site cysteine residues. Mtb ALDH detoxifies aldehydes, using a nucleophilic active site cysteine to form an oxyanion thiohemiacetal intermediate, whereas MtMetAP’s active site cysteine is essential for substrate recognition. The P450s metabolize various endogenous and exogenous compounds. Targeting these critical active site cysteine residues could disrupt enzyme functions, presenting a promising avenue for developing anti-mycobacterial agents.
Access status: Open Access ,
Composites of Shellac and Silver Nanowires as Flexible, Biobased, and Corrosion-Resistant Transparent Conductive Electrodes
(John Wiley & Sons Ltd., 2025) Hussein, Rahaf Nafez; Gomes, Tiago Carneiro; Ng, Eliza; Rondeau-Gagné, Simon; Carmichael, Tricia Breen
Silver nanowires (AgNWs) are a promising material to replace indium tin oxide as transparent conductive electrodes (TCEs) in next-generation flexible optoelectronics. AgNWs are more environmental friendly than indium tin oxide, and offer solution processability, high conductivity, and high optical transparency. Embedding AgNWs at the surface of a polymer matrix creates a planar, conductive surface that is ideal for use in thin-film devices. However, a barrier to practical use is corrosionin the ambient environment, which damages the AgNW network and reduces the workable life span. This study presents the use of shellac, an eco-friendly natural biopolymer, as a planarizing and protective matrix for AgNWs. Shellac has a long history as a coating due to its excellent film-forming ability and barrier properties, yet it has been largely unexplored in electronics. Here, the first shellac-based TCE comprising a AgNW network embedded at the surface of a shellac matrix is reported. Shellac-AgNW TCEs provide high conductivity and optical transparency, as well as mechanical stability under tensile strain. They also effectively function as TCEs in light-emitting devices. Furthermore, the barrier properties of shellac protect AgNWs from corrosion in humid air and corrosive acid vapors. These results position shellac as a sustainable alternative to persistent synthetic polymers, in flexible electronics.
Access status: Open Access ,
Green Video Transcoding in Cloud Environments Using Kubernetes: A Framework With Dynamic Renewable Energy Allocation and Priority Scheduling
(IEEE, 2025-07-11) Beena B.M. a Send mail to Beena B.M. ; b ; a ; a ;; Ranga, Prashanth Cheluvasai; Chowdary, Vinitha; Gamidi, Rohan; Hemasri M.; Muppala, Tejaswi
Video content continues to be a major source of Internet traffic, with a growing demand for high-quality, on-demand videos. This leads to significant energy consumption across cloud servers. Conserving energy and improving energy efficiency in cloud servers is a major challenge. The growing demand for video transcoding services and increasing concerns over energy consumption necessitate systems that balance processing power with energy usage. The research addresses these challenges by developing a green, energy-aware video transcoding system that predicts energy availability from renewable sources (solar and wind) using machine learning techniques and optimizes tasks allocation. The system utilizes a Kubernetes-managed backend to dynamically scale resources for FFmpeg-based transcoding while prioritizing renewable energy, minimizing grid usage utilizing the advanced machine learning models, including Random Forest, XGBoost, and CatBoost, predict energy production and guide task assignments. The integration of predictive analytics with Kubernetes’ Horizontal Pod Autoscaler (HPA) allows dynamic workload distribution, ensuring optimal energy utilization. Additionally, the system incorporates real-time energy monitoring to adjust task scheduling based on fluctuations in renewable energy availability. Two novel scheduling algorithms, Dynamic Renewable Energy Allocation (DREA) and Energy-Aware Priority Scheduling (EAPS), enhance energy efficiency. DREA allocates tasks to energy zones based on real-time renewable availability, while EAPS prioritizes tasks by urgency and energy needs, deferring low-priority tasks to periods of high renewable availability. These green strategies minimize reliance on non-renewable sources while maintaining performance and scalability. The system’s modular design allows easy integration with various cloud platforms, increasing its applicability in real-world scenarios. Furthermore, extensive scalability tests demonstrate that the proposed approach maintains efficient task execution even under high workloads, making it suitable for large-scale cloud environments. By reducing energy consumption and carbon footprint, this framework contributes to the advancement of sustainable cloud computing solutions.
Access status: Open Access ,
Regional cerebral pulsatile hemodynamics during isocapnic and poikilocapnic hyperthermia in young men
(American Physiological Society) Skaper, Spencer J. a Send mail to Skaper S.J. ; b ; b ; . c ;; Shepley, Brooke R.; Wafai, Ibrahim Amr; Ainslie, Philip N.; Bain, Anthony R.; Smith, Kurt J.
Hyperthermia is known to induce hypocapnia-driven reductions in cerebral blood flow; however, it is unknown if it causes changes in hemodynamic pulsatility that negatively influence cerebrovascular function. This retrospective analysis aimed to assess cerebrovascular hemodynamic pulsatile buffering (damping factor; DFi) during poikilocapnic (HT) and isocapnic (HT-C) hyperthermia. We hypothesized that HT would reduce cerebral DFi, while HT-C would attenuate the reduction in DFi by limiting increases in resistance. Ten healthy males were passively heated +2°C from normothermia (BL). Blood flow through the internal carotid artery (ICA) and vertebral artery (VA) was measured using vascular ultrasound. Blood velocity through the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) was measured using transcranial ultrasound. DFi was calculated as the ratio of proximal to distal pulsatility index (PI): Anterior cerebral DFi = PIICA/PIMCA; Posterior cerebral DFi = PIVA/PIPCA. Anterior DFi decreased in both HT (1.08 ± 0.19 a.u; p = 0.007) and HT-C (1.12 ± 0.231 a.u; p = 0.021) conditions from BL values (1.27 ± 0.14 a.u). No changes were observed in posterior DFi, p = 0.116. Irrespective of PaCO2 clamping, both hyperthermic conditions reduced anterior DFi, suggesting other mechanisms are responsible for cerebrovascular hemodynamic buffering. Posterior DFi responses were not observed, suggesting preferential buffering of the hyperthermic posterior circulation (VA–PCA).